This book features the most recent advances in 3D ultrasound of the fetal heart, with an emphasis on practical applications, including both technical and clinical aspects. It presents a detailed description of how to obtain standard views using 3D ultrasound and discusses their accuracy in diagnosis of congenital heart diseases. It also covers such topics as the use of Color Doppler, Inversion Mode, B Flow, Glass Body, and Tomographic Ultrasound Imaging for 3D ultrasound scans, as well as STIC with HDlive and HDlive silhouette and their application, especially in conotrucal anomalies and septal defects. The use of 3D ultrasound in venous connection anomalies and right-sided heart anomalies are also demonstrated in detail. An entire chapter is devoted to applications of 3D ultrasound during the first trimester, including assessment of fetal heart function and functional anomalies. New applications and perspectives are also addressed. With contributions from leading experts in the field, 3D Ultrasound of the Fetal Heart is a must-read for medical professionals, researchers, and students seeking to master the intricacies of three-dimensional ultrasound for fetal heart assessment. It bridges the gap between foundational knowledge and cutting-edge applications, ensuring a comprehensive and up-to-date understanding of this transformative imaging technique.

3D bioprinting in Cancer Applications is an all-encompassing guide covering both fundamentals concerning biofabrication principles and intricate protocols for precise construction of biomimetric 3D systems supporting advanced cell culture development that faithfully recapitulates human disease hallmarks, with a special focus on cancer. This title fills the void left by existing publications overlooking essential aspects associated with combining multimodal medical imaging alongside precision cancer treatment options. In 12 chapters 3D bioprinting in cancer applications leads the reader from an introduction to bioprinting technologies for cancer models, to models for immunotherapy and tumour-immune interaction, to biomimetrics 3D models to the applications of all these models in 3D bioprinted cancer models . 3D bioprinting in cancer applications uniquely combines distinct modalities under a unified framework suitable not only for seasoned veterans but also newly minted trainees encountering these sophisticated practices for the first time. - Gives comprehensive insights on the use of phytocompounds in the synthesis of eco-friendly nanoparticles for enhanced drug delivery in cancer applications - Provides concise updates on fresh discoveries in 3D printed biotechnologies - Includes high-resolution depictions to enhance accessibility while avoiding too many lengthy equations or calculations impeding quick absorption of fundamental ideas - Contributed by distinguished investigators across multiple countries and different specialties critical for mastering 3D bioprinted models

Advances in Biomembranes and Lipid Self-Assembly, Volume 41 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

This volume maintains the structure of previous ATSN series volumes, offering a balanced distribution of chapters that cover recent advances in neurosurgery and reviews of major neurosurgical conditions.Key sections of the volume provide a detailed review of tumors, including those of the optic pathways, hypothalamus, and pituitary adenomas. These sections highlight the renewed interest in surgical options for these tumors, emphasizing multi-specialist treatment approaches. The initial chapters focus on the development of instruments and techniques that facilitate minimally invasive approaches to various regions of the brain and cranio-vertebral junction. The volume also includes a chapter on colloid cysts of the third ventricle, which complements the discussion of surgical approaches for anterior skull base and frontal basal region pathologies. Other chapters are dedicated to cerebral arterial aneurysms and arteriovenous malformations, exploring the advantages of combined therapeutic strategies for safer and more effective management of these complex lesions. The final chapters investigate the benefits of complete excision of spinal lipomas versus partial resections and the more extensive excision of brain tissue harboring a glioblastoma (lobectomy) versus simple resection of the tumor and its infiltration into the surrounding brain parenchyma. Overall, the book is primarily aimed at mature and experienced neurosurgeons, but it is also beneficial for younger practitioners. It emphasizes a continuous reconsideration of well-known diseases in terms of new approaches that combine increased efficacy with decreased risk for the patient.

Patients with skeletal dysplasia are at greater risk for adverse events, including death, during or shortly after their anesthetic care. Due to advancements in medical and surgical treatment modalities, patients with skeletal dysplasia now enjoy a longer life span, emphasizing the importance of broader awareness and deeper understanding of the specialized anesthetic management required to ensure their safety and successful outcomes. This book provides a comprehensive overview of anesthetic care and management tailored specifically towards various forms of skeletal dysplasia. The chapters are organized into sections that focus on the different forms of skeletal dysplasia and their associated co-morbidities. They provide insights on how to anticipate and manage potential complications that may occur during the anesthetic care of these complex medical patients. Additionally, the book highlights the patient’s perspective, shedding light on the challenges individuals with skeletal dysplasia encounter in accessing appropriate anesthesia care. Intended primarily for practitioners of anesthesia, sedation, and critical care, this publication also serves as a resource for individuals with skeletal dysplasia who require anesthesia care. An understanding of the anesthesia process by the patients and families enables them to choose optimal care for a successful outcome.

This book provides a comprehensive introduction to the development and application of near-infrared fluorescence (NIRF) in cancer surgery. It thoroughly examines the history, principles, agents, functions, and devices associated with NIRF, along with the latest preclinical research and clinical applications. Special emphasis is placed on the advancements in the second NIRF window and its global implementation in cancer surgery, including innovative molecular imaging technologies in clinical translation. Additionally, the book explores the limitations and potential solutions of NIRF, offering insights into its future trends and perspectives. It serves as a valuable resource for university researchers, surgeons, radiologists, and both undergraduate and graduate students in medicine.

This book discusses current concepts and future translational possibilities of Artificial Intelligence (AI) in human healthcare and diseases. The initial chapter reviews the application and integration of AI and multi-omics to develop novel diagnostic and therapeutic strategies. The book chapter also explores the recent advances in data-driven approaches that aided state-of-the-art AI for biomarker discovery and better disease diagnosis. The book also offers computational and oncological prospects for the role of AI in radio genomics, as well as its offers, achievements, opportunities, and limitations in the current clinical practices. The chapters further cover the role of the current state of AI in Cardiovascular Disease, Obesity and Diabetes, Neurological Diseases, and Infectious Diseases. Towards the end, the book highlights the use of AI in diverse pharmaceutical industry sectors, including drug discovery and development, drug repurposing, and improving pharmaceutical productivity. This book is handy for basic, translational, clinical & interdisciplinary researchers and bioinformaticians.

This book provides a wide-ranging overview of artificial intelligence (AI), machine learning (ML) and deep learning (DL) algorithms in ophthalmology. Expertly written chapters examine AI in age-related macular degeneration, glaucoma, retinopathy of prematurity and diabetic retinopathy screening. AI perspectives, systems and limitations are all carefully assessed throughout the book as well as the technical aspects of DL systems for retinal diseases including the application of Google DeepMind, the Singapore algorithm, and the Johns Hopkins algorithm. Artificial Intelligence in Ophthalmology, 2nd edition has been fully revised with the latest advancements in the field. New chapters highlight topics such as the threats to the validity of the predictive system performance for ophthalmology, challenges in the deployment of AI for diabetic retinopathy screening and the use of AI in calculating the IOL power to name just a few. This book meets the need for a resource that reviews the benefits and pitfalls of AI, ML and DL in ophthalmology. Ophthalmologists, optometrists, eye-care workers, neurologists, cardiologists, internal medicine specialists, AI engineers and IT specialists with an interest in how AI can help with early diagnosis and monitoring treatment in ophthalmic patients will find this book to be an indispensable guide to an evolving area of healthcare technology.

This book systematically describes details in Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). The chapters focus on the development history, applied anatomy, mechanism of action, specific methods of administration of the various types of current ALPPS procedures (from classical ALPPS to various modified procedures), the preoperative evaluation, case selection (indications and contraindications), and surgical planning, as well as the postoperative management and follow-up treatment. It also introduces the progress of international research on ALPPS, as well as the ALPPS modeling of the research. It will be a helpful reference for hepatobiliary surgeons and oncologists to learn the latest theoretical and technical knowledge about ALPPS.

The field of adolescent dermatology is a growing topic amongst pediatricians and adolescent medicine providers. There are numerous conditions specific to the adolescent population that require specialized care. This book details the diagnosis and management of a variety of adolescent skin diseases. The text is organized into eight different sections. The first section describes the most common conditions seen in the adolescent population, acne and perioral dermatitis. Sections two and three cover cutaneous infections and infestations and eczematous papulosquamous issues. The fourth section focuses on autoimmune and rheumatologic conditions while part five provides reactions to external causes. The final three sections detail genodermatoses and genetic conditions in dermatology, tumors and nodular lesions and lymphocytic disorders. Since publication of the previous edition, there have been several important developments in the field. One major issue that was not addressed is skin cancer in adolescents. Due to tanning beds and other factors, the prevalence of skin cancer in adolescents is rising. Various diagnoses and managements are addressed. Infections from body art such as tattoos and piercings is also a hot topic that has been added. The number of youths getting tattoos and piercings has also risen and subsequently so have complications from them. Now fully revised and expanded. The Atlas of Adolescent Dermatology is a valuable resource for dermatologists, adolescent medicine specialists, family medicine practitioners, and primary care physicians.

Autoimmune Hemolytic Anemias: A Practical Guide is a comprehensive update of autoimmune hemolytic anemias, a rare disease that is sometimes difficult to diagnose and manage. This book describes historical concepts, diagnosis, differential diagnosis, pathogenesis, classification, standard therapy, new treatments, secondary forms such as lymphoproliferative, immunodeficiency, Evans, other autoimmune diseases. It is a practical guide to manage transfusions and anticoagulation as well as monitoring infections and preventive measures. This book is useful to researchers, clinicians, doctors and students working in hematology, transfusion centers, immunohematology labs and internal medicine.

This quick-reference guide is the first book written specifically for the many third- and fourth-year medical students rotating on a Bariatric Surgery⁠ service. The book focuses on the diagnosis and management of the most common pathologic entities. Each chapter covers history, physical examination, imaging, and common diagnoses. For each diagnosis, the book sets out the typical presentation, options for non-operative and operative management, and expected outcomes. Chapters include key illustrations, quick-reference charts, tables, diagrams, and bulleted lists. Students can read the text from cover to cover to gain a general foundation of knowledge that can be built upon when they begin their rotation, then use specific chapters to review a sub-specialty before starting a new rotation or seeing a patient with a sub-specialty attending. Practical and user-friendly, Bariatric Surgery Clerkship is the ideal, on-the-spot resource for medical studentsand practitioners seeking fast facts on diagnosis and management. Its bullet-pointed outline format makes it a perfect quick-reference, and its content breadth covers the most commonly encountered problems in clinical practice.

The objective of this text-atlas is to examine the bicuspid aortic valve syndrome (BAV) holistically. The various chapters deal with epidemiology, morphological spectrum, embryology, associated congenital heart disease, genetics and familiarity, natural history, including clinically relevant valve complications (stenosis, regurgitation, endocarditis) and/or vascular complications affecting the thoracic aorta (dilatation, aneurysm, dissection) that require close clinical follow-up. In addition, multimodal imaging and surgical and transcatheter therapeutic options will be described. To the best of our knowledge, this will be the first illustrated monograph on this topic and will be enriched with numerous original illustrations.Offering in-depth visual representations, clinical insights and comprehensive data, it will provide experts with the tools they need to improve understanding and treatment of this unique heart conition, advancing patient care and research in the field of cardiovascular health.

This book presents state-of-the-art knowledge regarding fluid and imaging biomarkers of neurodegenerative disorders, including Alzheimer disease and related dementias (ADRD). A cadre of the top experts in the field discuss the diagnostic and prognostic value of established and emerging biomarkers in ADRD, their ability to track or monitor disease progression or predict cognitive outcomes, and their potential as novel therapeutic targets. Biomarkers are discussed both in the context of specific disease mechanisms, including amyloid, tau, and synuclein pathologies, endothelial, vascular, neuronal, and synaptic injury, and glial reactivity as well as a wide spectrum of neurodegenerative disorders that encompass various pathologies. Multi-omics approaches in ADRD biomarker and drug target discovery including proteomics, genomics, and transcriptomics are covered. Importantly, the authors highlight the need to integrate biomarkers into various stages of ADRD drug development to accelerate drug discovery and approval. The book provides in-depth insight regarding significant progress in ADRD biomarker research over the last decade, addresses potential challenges in the translation of ADRD biomarkers into the clinic, and proposes important directions for future research.

This textbook serves as a comprehensive resource for readers interested in applying the principles of engineering mechanics to analyse the mechanical and structural functions of the musculoskeletal system. Over the past few decades, orthopaedic practice has strongly been influenced by the contributions from mechanical analysis and design. This book sequentially presents basic concepts and applications necessary for understanding a biomechanical system. The book is specially focussed on analysis and design of orthopaedic implants used to treat skeletal diseases and disorders. The book begins with an introduction to the anatomy, physiology, and movements of human body and its mechanical analogy, followed by chapters on basic biomechanics of various joints and spine. It elaborately discusses the gait analysis and measurement techniques and systematically presents the quantitative estimation of musculoskeletal forces (joint forces and moments, muscle forces) using the fundamental concepts of joint dynamics (kinematics and kinetics), with relevant solved examples and exercises to impart basic understanding and knowledge to the students. It also discusses the basic concepts of mechanics of deformable bodies relevant for bone tissue as well as implanted bone structure, common failure mechanisms of implanted bone structure and biomaterials used in orthopaedic implants, and the steps involved in finite element modelling and analysis of implant-bone structures. Other topics covered include various theories, mathematical formulations, the computational framework of bone remodelling and bone ingrowth, mechanobiology based mathematical models of tissue differentiation, and simulations on tissue ingrowth have been presented along with the outcomes of our research activities, which may help and inspire the students to pursue research in this field.

This volume outlines the theoretical and ethical commitments for forensic psychologists in the struggle for Black liberation and details areas of focus for practice and research. It aims to highlight how Black forensic psychologists have historically engaged in these areas through the lens of Black psychology. The chapters that follow extensively cover the often overlooked relationship between forensic psychology and Black liberation, including chapters on: • Black forensic psychologists whose work contributed to political movements; • The psychologist’s role in supporting reparations movements; • The importance of community healing collectives as alternatives to incarceration and policing; • Recommendations for introducing Black psychology into forensic practice. Examining the role of forensic psychology within America’s racialized carceral systems, this book critically analyzes how psychological research and practice influence legal and material outcomes for Black individuals. Grounded in historical context and contemporary case studies, it offers essential insights for practitioners, activists, and scholars committed to challenging the systemic harms that disproportionately affect Black communities within the most incarcerated nation in the world.

The series "Stem Cell Innovation in Health & Disease" is a timely and fascinating collection of information and new discoveries and provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. The Cardiovascular System, Volume 6 addresses the recent data accumulated on the potential applications of stem cells to treat diseases and disorders of the cardiovascular system. This volume will highlight the recent developments of cutting-edge in vitro and in vivo research tools and approaches, including the human and murine organoid cultures, genetic editing in vitro and in vivo, human iPSC models of diseases, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to treat cardiovascular system disorders and diseases. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation; and is contributed by world-renowned authors in the field. - Provides cutting-edge research to understand stem cell functions used in disease and disordertreatments of the cardiovascular system - Develops processes to bring stem cells from bench to bedside - Includes up to date references on stem cell biology and function in common cardiovascular system diseases and disorders

This book aims to offer a concise and up-to-date overview of carotid artery diseases and their treatments. Authored by experienced professionals, it caters to a range of specialists in Vascular Surgery, Interventional Radiology, Neurology, and general medicine, providing a comprehensive understanding of carotid artery conditions and available treatment modalities. With a practical approach and clear language, its primary objective is to serve as a quick and useful resource for young doctors interested in this field. Notably, the inclusion of high-quality images and the correlation of imaging findings with operative outcomes enhance its value. By combining theoretical knowledge with practical applications, this book equips readers with the necessary tools to navigate the complexities of carotid artery diseases effectively.

Richly illustrated with clear drawings and photographs, as well as with instructional audio and video files, this is the first and only book dedicated solely to the in-depth, state-of-the-art, multidisciplinary diagnosis and management of cleft palate and velopharyngeal dysfunction. Co-edited by a pediatric plastic surgeon and a speech scientist who are internationally-recognized leaders in the field, and with chapters written by well-known experts, the work is intended to fill the need for a comprehensive text to address the interdisciplinary assessment and management of cleft palate and velopharyngeal dysfunction. Cleft Palate and Velopharyngeal Dysfunction will serve as a valuable resource for surgeons, speech pathologists and others that care for children and adults with cleft palate and velopharyngeal dysfunction.

This handbook addresses evidence-based training practices for individuals providing applied behavior analysis (ABA) interventions for individuals on the autism spectrum. It provides specific examples of interventions across various contexts and skills and addresses the importance of effective and efficient training as it relates to ABA-based interventions for individuals on the autism spectrum. Additional areas of coverage include, but are not limited to, staffing, clinical judgment, shaping, mealtime interventions, qualities of effective trainers and developing effective training systems. Key areas of coverage include: • Training versus mentorship. • Developing systems and contingencies related to training within an organization. • Ensuring a common vocabulary with trainers and trainees. • Development of clinical judgment. • Cultural considerations within training. The Clinical Handbook of Autism Intervention Training is a must-have resource for clinicians, therapists, and other practitioners and professionals as well as researchers, professors, and graduate students across such interrelated disciplines as clinical child, school, and developmental psychology, child and adolescent psychiatry, clinical social work, public health, rehabilitation medicine/physical and occupational therapy, special education, pediatrics, and neurology.

This third edition atlas provides the most current techniques and methods for treating both benign and malignant urologic conditions using the most modern robotic platforms and equipment available to date. Robotic surgery has had a very well-established and increasing role in the field of urology for the past two decades, in many cases almost completely replacing traditional open and laparoscopic approaches. Robotic surgery has continued to expand and has been applied to urologic conditions in both adult and pediatric patients. In addition, advancements in robotic technology have opened the door to single-site (vs multi-port) surgeries, further reducing the morbidity and improving the cosmesis for many urologic procedures. The book begins with a guide to getting started in robotic surgery with new chapters on robotics training and performance improvement. From here, the book comprehensively and systematically covers a wide range of surgical procedures, including surgeries of the upper and lower urinary tract using the daVinci Xi platform, robotic pediatric urologic surgeries, and single port (daVinci SP) robotic surgery. A discussion of the past, present, and future of robotic surgical platforms wraps up this comprehensive guide. Each chapter is written by internationally-recognized leaders in the field in a consistent step-by-step format to help the audience learn how to expand their robotic surgical techniques and capabilities for their patients. The Comprehensive Atlas of Robotic Urologic Surgery, Third Edition is a singular resource for individuals who are involved in robotic surgery including urologic surgeons, trainees, nurses, physician assistants, and anesthesiologists.

This book is written for clinicians who care for patients with hepatocellular carcinoma (HCC) as well as health services researchers doing work in this area. The Editors and authors cover some of the emerging controversial topics that come up in HCC clinical practice and research. There are over 30 questions ranging from screening and diagnosis to therapeutics and survivorship. Chapters are begin with a controversy and the authors defend or refute the question. Comprehensive and unique, this book aims to help with management of this patient population.

Culinary Medicine is a field of growing interest and importance. Medical doctors are increasingly aware that they have not received adequate training in this field in medical school, residency or fellowship, and patients frequently ask their doctors about appropriate diets for spine and joint conditions. Doctors are often left to “google” the question, shrug their shoulders, or send the patients to nutritionists who don’t have specific training on culinary medicine for spine and joint issues. This unique book provides evidence-based clarity on the questions of what food choices are appropriate for promoting and maintaining a healthy musculoskeletal system. The book opens with the essentials of Culinary Medicine, an overview of the anti-inflammatory diet, and the importance of the gut microbiome to overall health and well-being. Subsequent chapters discuss its application to a variety of spine and joint conditions, including degenerative disc disease, spinal stenosis, osteoarthritis, tendinopathies, muscle growth and aerobic workout. Practical pearls are the provided for how to incorporate Culinary Medicine into one's practice.

This groundbreaking volume brings together leading researchers to explore the latest findings on the psychological and physiological factors that shape decision-making. It offers a uniquely multidisciplinary perspective, integrating insights from neuroscience, economics, public policy, and other fields to provide a comprehensive understanding of how we make choices in both personal and professional contexts. Designed for researchers, professionals, instructors, and students interested in decision science, this book delves into several key areas. It explores the cognitive biases and heuristics that influence our decisions. The book also examines the role of emotions and intuition in decision-making. Additionally, it investigates the neuroscience behind information processing and judgment. It also provides strategies we can use to make better decisions in real-world settings. The chapters, written by experts in the field, cover a wide range of topics ranging from the foundations of decision theory to the latest research on the neural bases of decision-making, providing readers with a rich understanding of the subject. Through its multidisciplinary approach and emphasis on practical applications, this volume offers readers valuable insights and tools for enhancing their own decision-making skills. Whether you are a researcher studying decision-making processes, a professional looking to make better judgments in important situations, or an instructor teaching decision science, this book provides a comprehensive and accessible resource that will deepen your understanding of this critical area of human behavior.

A novel account of the explanatory role of representation in both the cognitive sciences and commonsense practice that preserves the virtues without the defects of the prevailing two views about mental representation. Philosophers of mind tend to hold one of two broad views about mental representation: they are either robustly realist about mental representations, taking them to have determinate, objective content independent of attributors’ explanatory interests and goals, or they embrace some form of anti-realism, holding that mental representations are at best useful fictions. Neither view is satisfactory. In Deflating Mental Representation, Frances Egan develops and defends a distinctive third way—a view she calls a deflationary account of mental representation—that both resolves philosophical worries about content and best fits actual practice in science and everyday life. According to Egan’s deflationary account, appeal to mental representation does indeed pick out causes of behavior, but the attribution of content to these causes is best understood as a pragmatically motivated gloss, justified in part by attributors’ explanatory interests and goals. Content plays an explanatory role in the deflationary account, but one quite different than that assumed by robust representational realists. Egan also develops a novel account of perceptual experience as a kind of modeling of our inner lives by aspects of external reality and explains the role of appeal to representation in this process.

Depressive and Bipolar Disorders: Diagnosis, Neurobiology and Therapeutic Innovations offers a comprehensive reference on affective disorders, providing clinical practitioners with invaluable insights into recognition, diagnosis, and treatment strategies. Dr. Vázquez meticulously examines the complexities of major depressive disorder and bipolar disorder, shedding light on the challenges of distinguishing between these conditions, particularly when manic or hypomanic episodes are not readily apparent. From historical perspectives to the latest DSM criteria, this book thoroughly examines depressive disorders and the variability in their clinical course.By highlighting mixed states and their implications for suicide risk, exploring the neurobiology and genetics underlying mood disorders, and discussing practical diagnostic tools and pharmacological interventions, this book equips readers with essential knowledge. Accessible language and comprehensive coverage make this an indispensable resource for healthcare professionals, offering insights that can profoundly impact individuals grappling with these challenging mental health conditions. - Explores major depressive disorder and bipolar disorder, bridging the gap between mood poles and addressing variability in epidemiology and clinical courses - Provides clinical practitioners with essential tools for recognition, diagnosis, and treatment, including discussions on diagnostic tools, symptom assessment scales, and pharmacological interventions - Written in an easily understandable manner, making it suitable for healthcare professionals across disciplines

The problems related to clinical distractions have grown in a brief amount of time. In addition to the expended use of electronic medical records, handheld technologies, and AI, staffing issues are reaching crisis levels. There is a considerable threat to patient safety, professional performance, and wellness. This book exposes the breadth or risks covered in the previous edition while expanding into new topics. The team of authors represents a diverse group of experts that offer different perspectives. Distracted Doctoring is written for physicians, including anesthesiologists, surgeons and general practitioners, PAs, NPs, nurses, pharmacists, technologists, other members of the health care team (clinical and non-clinical), researchers, health care administrators and students.

Embracing the Complexity of Gender examines the heart of a modern gender revolution, exploring the dynamic and multifaceted nature of gender in contemporary society. Spurred by landmark events such as the legalization of same-sex marriage and the rise of transgender visibility, this revolution has ignited passionate debates and a heightened interest in understanding gender's complexities. From legal battles over all-gender bathrooms to corporate decisions challenging traditional gender norms, the discourse around gender has never been more vibrant or contentious. This book combines a developmental and intersectional feminist approach with accessible, engaging content. By including discussion questions and clear definitions of key terms, the book ensures that complex ideas are understandable for readers at all levels. Drawing on psychological evidence and theoretical perspectives, this book challenges the gender binary and emphasizes the importance of social justice and inclusion.

This textbook provides the fundamental of children’s critical care from a European perspective. It offers a valuable guide for beginners as well as for clinicians working in Intensive Care and allied professionals including the role of an ICU in a modern children’s hospital, specific situations and clinical practice achievements including techniques and the more appropriate therapies to be applied in different conditions. A section is devoted to specific organs – lung, heart and circulation, kidney and RRT, gut, brain, liver and pancreas, inflammation, immunity and sepsis, metabolism and metabolic diseases in ICU – whilst other to Cardiac Critical Care and Neuro Critical Care. Edited and written by renowned key opinion leaders in the field, all chapters use a learning-oriented style, with practical examples, key points and take-home messages, so that readers can easily learn the content and, at the same time, apply what they have learned in the clinical setting. ESPNIC Children’s Intensive Care Textbook is also the prime textbook for the EPIC Diploma, matching the published international consensus curriculum and it is accompanied by an MCQ, in the fashion of the exam style.

The book covers all aspects of eTEP repairs for ventral and incisional hernias. It includes a detailed depiction of the relevant abdominal wall anatomy and core concepts required prior to performing the procedure. It conveys the core techniques of interparietal surgery, and the technical modifications required based on clinical features with the help of operative images and anatomical illustrations. It assists the budding hernia surgeon negotiate the learning curve for this rather challenging set of procedures which have great potential to improve patient outcomes. The book serves as a comprehensive guide for both early-career and veteran surgeons who are aiming to learn the eTEP technique. It is useful for postgraduates and fellows as well.

Now in a revised second edition, this book is a comprehensive guide to teach surgeons, surgical fellows and surgical residents, regardless of their specialty, the skills to appraise what they encounter in the surgical literature. Surgeons need to be able to understand what they read before applying the conclusions of a surgical article to their practice. As most surgeons do not have the extra training in health research methodology, understanding how the research was done, how to interpret the results, and finally deciding to apply them to the patient level can be a difficult task. Chapters included here explain the methodological issues pertaining to the various study designs reported in the surgical literature. Readers are taught how to search the literature for the best evidence that will answer the surgical problem under discussion. An identified article that seems relevant to the problem under investigation can be appraised by addressing three key questions: 1) Is the study I am reading valid? 2) what are the results of this study? and 3) can I apply these results to my patients? Chapters new to this edition discuss cluster RCTs, network meta-analyses, enhanced recovery after surgery (ERAS) and core outcome sets (COS). While the primary goal of Evidence-Based Surgery is to teach surgeons how to appraise the surgical literature, an added benefit is that the concepts explained here may help research-minded surgeons produce higher quality research.

In the intricate landscape of childhood emotional and behavioral challenges, disruptive mood dysregulation disorder (DMDD) stands as one of the most daunting. Characterized by intense irritability and explosive outbursts, DMDD can transform the journey of parenting and teaching into a relentless storm, leaving families and educators searching for guidance and support. This book offers a beacon of hope as well as a comprehensive resource crafted for those dedicated to nurturing children with DMDD. Key areas of coverage include: !-- [if !supportLists]--· !--[endif]--Biological, psychological, and environmental factors contributing to DMDD and how to recognize and assess its symptoms effectively. !-- [if !supportLists]--· !--[endif]--Evidence-based approaches to assessing and treating DMDD, from parent training and therapeutic interventions to medication management. !-- [if !supportLists]--· !--[endif]--The eight guideposts for building resilience to help children with DMDD navigate their emotions, develop problem-solving skills, and cultivate self-discipline and empathy. !-- [if !supportLists]--· !--[endif]--Real-life inspirational and practical wisdom from the experiences of families who have courageously and lovingly faced the challenges of DMDD. !-- [if !supportLists]--· !--[endif]--Strengthening home and school partnerships to ensure that children with DMDD receive the support and accommodations they need to thrive academically and socially. Finding the Calm Child Within is a testament to the power of resilience and the potential for growth and transformation in a child’s life. It extends beyond DMDD, offering valuable insights for managing a range of emotional and behavioral challenges. The book is an invaluable resource for parents, caregivers, educators, and mental health professionals.

This volume explores adaptation, recovery, and regeneration, including training foundations, and the issue of tissue damage during physical activity – from basic and applied science perspective, and clinical/practitioner viewpoint. The chapters examine our current understanding of the etiology of tissue damage, and explore current therapy techniques to remediate tissue damage post-injury, as well as strategies to minimize the occurrence of injury through proper preparation. The book employs a multidisciplinary approach to study how to best translate, utilize, and communicate the knowledge developed from current research into actual practice. In addition, the book presents a crucial perspective on how current practice should voice issues and questions to fuel further research in the field. This material will be useful for upper undergraduate degree programs, as well as post graduate programs in kinesiology, physical therapy, occupational therapy, bio-engineering and other health sciences. It is also a good reference for practitioners and researchers in fields involving musculoskeletal heath and sports medicine, and who are interested in the area of tissue adaptation, recovery, and regeneration.

The purpose of this fifth volume in the Global Virology series is to describe and propose vaccines, focusing primarily on viral vaccines. In addition to human vaccines, animal viral vaccines are included since animals are used in vaccine research, and the spread of diseases to, from, and among animals, birds, and humans permeates the ecosystem. Due to climatic, geographical, and social factors, there is increased global spread of viruses and other infectious agents. Contributory factors include global warming, spread of vectors, increased human travel, encroachment into animal and avian environments, war, pestilence, malnutrition, and environmental, economic, and social collapse. GVV will address vaccines for many of the viruses addressed in previous series volumes, as well as for viruses not previously covered, and novel and future vaccine technologies. Advances in vaccine effectiveness and molecular engineering approaches are included, such as gene therapy, and CRISPR technologies.

This book presents a bold governance blueprint for an era in which mental health systems face a historic transition: as care delivery becomes increasingly shaped by code, platforms, and predictive algorithms, new governance frameworks are needed to protect equity, ethics, and human-centered leadership. At the core of this blueprint is the 5P Model – Predictive, Preventive, Personalized, Participatory, and Precision-based – a transformative framework for building equitable, effective behavioral health systems in the age of AI. The book introduces the Digital Behavioral Health Expert (DBHE), a new professional role designed to bridge clinical care, policy systems, and digital infrastructure. Unlike traditional mental health models that focus on professional interaction alone, the DBHE enables coordination across platforms, stakeholders, and jurisdictions – turning governance into a strategic, ethical, and human-centered function. Designed for stakeholders across the ecosystem – policymakers shaping regulation, managers implementing care systems, clinicians navigating hybrid models, developers building ethical tools, and investors backing scalable solutions – this book equips each with strategic insight for a digitally governed future of mental health. "A timely vision for ethical, inclusive governance in digital mental health." — Professor Anil Thapliyal, Executive Director, eMental Health International Collaborative (eMHIC)

This handbook provides comprehensive coverage of assessment instruments used in mindfulness research. It discusses traditional and modern approaches used to develop psychometric measures and to establish their reliability and validity, such as classical test theory, item response theory and Rasch model, generalizability theory, facet benchmarking, and network analysis. The handbook provides information on conceptual foundations, development, and psychometric properties of assessment instruments used to measure mindfulness in children, adolescents, and adults. In addition, it provides similar information on scales used in specific contexts and for various purposes. It reviews behavioral, cognitive, and psychophysiological assessment measures of mindfulness. The handbook examines a broad range of psychological, physical health, and mental health, and related measures that are used in mindfulness research. This reference work enables researchers to choose appropriate measurement tools fora broad range of mindfulness research. Key areas of coverage include: Nature and theoretical foundations of assessment. Origins and definitions of mindfulness. Mindfulness scales for children and adolescents. Mindfulness scales for adults. Mindfulness scales for specific contexts and purposes. Mindfulness and Buddhist-related scales. Behavioral assessments of mindfulness. Cognitive and psychophysiological assessments of mindfulness. The Handbook of Assessment in Mindfulness Research is an essential reference for researchers, professors, and graduate students as well as clinicians, therapists, and other mental health practitioners in clinical psychology and affiliated medical and mental health disciplines, including complementary and alternative medicine, social work, occupational and rehabilitation therapy.

Handbook of Blockchain, Digital Finance, and Inclusion, Volume Three: Web3, AI, Privacy and Greentech presents the latest technological developments and innovations occurring in cryptocurrency. The book explores the hottest topics in this fast-moving area, emphasizing the financial opportunities made possible by cryptocurrencies, such as DePIN and decentralized finance while also presenting the theories and advances that have the potential to create additional opportunities in the convergence of blockchain with AI and privacy technology. Users will find this to be an important resource that bridges the gap between practical usability and academic perspective.This new volume continues the tradition of the first two, focusing on the latest trends, including Web3, Zero Knowledge Proof, Machine learning, Quantum Technologies, the Internet of Things in ESG, decentralized networks, digitalization, and more. It will serve as a valuable reference to an international audience that wants to learn not only about their own fields of specialization but also related fields. - Explains the practical consequences of these technologies and their economics to a broad spectrum of readers - Encompasses Web3, Zero Knowledge Proof, Machine learning, Quantum Technologies, the Internet of Things in ESG, decentralized networks, and digitalization - Provides sophisticated, in-depth summaries - Explains how blockchain technology provides greater efficiency and reduced cost for financial services

This book describes the state of the art of pediatric complex care, sharing the authors' decades of experience in an academic health center to illustrate points. The authors are pediatric generalist and subspecialist providers, among others, who care for children with medical complexity in a Pediatric Complex Care program. Children with medical complexity (CMC) are a small yet impactful pediatric population, a subset of children with special healthcare needs that include multi-system, non-categorical, chronic conditions, high resource and technology dependencies, medical fragility, and functional impairments. CMC do not fit into traditional systems of care. They require the continuous collaboration of pediatric subspecialists, community and public health partners, and family caregivers. The field of Pediatric Complex Care is rapidly evolving, yet lacks a well-prepared workforce built on clear educational competencies and clinical guidelines. In this compact volume, the authors review models of care for CMC, and how these models intersect with larger public health systems, dependent on collaborative networks of community-based and family partnerships. They explore ethical considerations, including implications for policy and practice. Among the topics covered are: The Specialty and Scope of Complex Care Pediatrics Ethical Considerations in the Care of Children with Medical Complexity Implications for Policy and Practice Healthcare Delivery for Children with Medical Complexity: The State of the Art and Future Directions is an essential resource for all medical professionals who care for CMC, public policy makers, medical educators, healthcare leaders, and community partners and stakeholders.

This edited volume explores current research and future developments in transplantation medicine. Key sections include advances in organ preservation, mechanical circulatory support, and emerging fields such as organ transplantation from cardiac death donors (DCD), pediatric application of ventricular assist device (VAD), immunological tolerance and xenotransplantation. With contributions from leading U.S. experts in pediatric VAD therapy, DCD heart and lung transplantations, combined heart and kidney transplantation, the book provides a forward-looking perspective on how these innovations will transform the field. The book also details the historical journey of organ transplantation in Japan, from its early challenges to the significant revival of heart transplantation in 1999. It presents the impressive clinical results achieved at the First Department of Surgery at Osaka University Medical School. Heart and lung transplantation: Historical Developments, Clinical Achievements, and Future Perspectives is essential reading for medical professionals, researchers, and students interested in the latest advances and future directions in organ transplantation.

This volume explores various aspects of reversible acetylation of histone and non-histone proteins, focusing on their roles in development, ageing and disease progression. It examines the biological consequences of modulating acetylation levels by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Covered are manipulations at multiple levels, from in vitro and in vivo studies to clinical trials and FDA-approved therapies. The book is divided in four parts: !--[endif]--Part I provides an overview of post-translational modifications in the context of development, ageing, neurodegenerative and cancer-related diseases. It highlights the role of histone acetylation in higher genome organization and explores the functions of the proteins involved. Part II focuses on the modulation of cytoskeleton-associated proteins through reversible acetylation. It examines how acetylation influences cytoskeletal compartments, thereby regulating cellular structure and function. Part III examines acetylation in the context of development. It describes acetylation as a key regulator of early embryogenesis, influencing chromatin structure and gene expression. Part IV discusses physiological and pathological aspects of histone and non-histone protein acetylation and its modulation by activators and inhibitors. The book is a valuable resource for scientists, clinicians and academic teachers alike.

Immuno-oncology and immunotherapy, Part D, Volume 196 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Investigating the endothelial-immune axis in cancer, Establishing Tyro3, Axl, and Mertk Chinese Hamster Ovary (CHO) Reporter Cell Lines for Cancer Immunology and Therapeutic Applications, Amino acid analog-based labelling of the immunomodulatory cancer secretome, Human and mouse iNKT cell expansion and engineering with viral vectors, Next-generation deconvolution of the tumor microenvironment with omnideconv, and much more. Additional sections cover Comprehensive prediction of tumor neoantigens with NextNEOpi, Ex vivo profiling of organotypic tumor spheroids in 3D microfluidic culture, A flow cytometry-based assay for evaluation of T cell activation and degranulation in coculture systems, An adenosine production assay suitable for 2D and 3D cancer cell culture, Determination of lactate in the tumor interstitial fluid, Combined in vitro differentiation and cell sorting-based isolation of highly pure mouse bone marrow-derived basophils, Organ-on-Chip immunostaining method for three-dimensional identification and study of immune cells responding to drug-treated tumor cells, and much more.

This contributed volume follows up and expands upon Target Pattern Recognition in Innate Immunity (2009), providing a much-needed update on an area that has surged to the forefront of medical research in recent years. From the initial idea of pattern recognition on microbial surfaces, innate immunity is now recognized as a key player in human health and disease, by virtue of its ability to regulate adaptive immune responses with important physiological and pathological consequences. This book presents cutting edge research and future perspectives on nearly all aspects of innate immunity. Coverage includes cells of the innate immune system, pattern recognition receptors and effector mechanisms, soluble PRRs and humoral factors, immune response to viral, bacterial, fungal, and parasitic pathogens, disease mechanisms, and comparative studies in non-mammalian innate immunity. It is an excellent introduction to the field for students, and state of the art reference for researchers and professionals.

Anatomy is intrinsically a three-dimensional and visual discipline. Anatomical education is therefore primarily delivered using physical and digital three-dimensional visual approaches to support student understanding of anatomy, including human body donor specimens and technology-enhanced learning resources. The Trans-European Pedagogic Anatomy Research Group (TEPARG) was founded in 2003 to promote scholarly, research-informed, and evidence-based approaches to the design and implementation of anatomical education. TEPARG brings together enthusiastic anatomy teachers and pedagogic researchers from across Europe and beyond to share good practice and create new projects in support of anatomical education. The work presented in this volume demonstrates careful consideration by the authors of several key areas within the current complex landscape of international anatomical education. This volume is presented in two subthemes, with the first section concerning broad considerations of modern anatomy curricula in England, Scotland, Wales, and Austria, and the second section involving discussion of pedagogic innovations for the delivery of anatomical education to learners and to the wider public in Italy, Spain, Australia, and the United Kingdom. The work presented in this volume will have implications for anatomical educators and pedagogic researchers in the anatomical sciences who are seeking to develop their own anatomy curricula, and to implement effective, evidence-based, and research informed visualization strategies and innovations into their teaching.

Procedures-based and easy to follow, Interventional Management of Pelvic Pain is a unique and practical guide to the treatment of chronic pelvic pain (CPP). Written by pain management specialists, this hands-on reference provides clear instructions on how to use interventional techniques to deliver pain relief for this common and often debilitating condition. It's an ideal resource for pain medicine practitioners and fellows, anesthesiologists, neurologists, PM&R specialists, gynecologists, orthopedic surgeons, and rheumatologists. - Provides up-to-date, expert guidance on pain management for gender affirmation surgery, pelvic interventions, hypogastric plexus block, neuromodulation, and much more. - Presents each nerve block chapter in a concise, templated format for quick and easy access to key information. - Covers indications, contraindications, precautions, complications, step-by-step procedural descriptions, and medications used. - Features full-color anatomic drawings, clinical photographs, and relevant imaging, including radiographs, ultrasound, and CT. - Offers clear guidance on the risks and benefits of each procedure or technique, and highlights potential pitfalls and how to avoid them. - Any additional digital ancillary content may publish up to 6 weeks following the publication date.

This book provides a state-of-the-art overview on the role of bioiron in health and disease. Iron is an essential constituent of simple and complex organisms and has played a critical role in the origin of life. Cells utilize iron for energy metabolism, oxygen transport, and several biochemical reactions due to its flexible coordination chemistry and its unique ability to serve both as electron donor and acceptor. The term “bioiron” was coined to emphasize the importance of iron in biology and medicine. Even though iron is an abundant metal, its bioavailability is limiting. This often leads to iron-deficient states, which manifest in anemia and other co-morbidities. In fact, iron deficiency is the most common medical condition worldwide. On the other hand, excess iron is potentially toxic due to its redox reactivity. Iron toxicity is illustrated in pathologies of iron overload disorders, such as hereditary hemochromatosis or iron-loading anemias. Deregulation of iron metabolism is also observed in prevalent metabolic, cardiovascular, or neurological disorders. Our knowledge of iron metabolism has dramatically increased during the last 30-40 years with the discovery of elegant iron homeostatic networks that operate at the cellular and systemic levels. These include the IRE/IRP regulatory system and the hepcidin/ferroportin axis. The iron hormone hepcidin has emerged as a master regulator of systemic iron traffic and as a pharmacological target for iron-related disorders. The book offers a comprehensive overview of the rapidly growing bioiron field and aims to attract the attention of students, basic scientists, and clinicians.

This comprehensive book offers an in-depth overview of laboratory diagnoses for both inherited and acquired thrombophilias, illuminating the complex interplay between genetic and environmental factors that contribute to venous thromboembolism. Beginning with foundational concepts in thrombophilia testing, the book systematically covers the diagnosis of key anticoagulant deficiencies, including protein C, protein S, protein Z, antithrombin, and plasminogen, as well as the critical evaluation of prothrombin G20210A and factor V Leiden mutations and other factors involved in thrombosis. It also addresses acquired thrombophilia, highlighting the significant impact of factors such as hyperhomocysteinemia and the influence of medications, lifestyle choices, and underlying health conditions on thrombosis risk. Each chapter clarifies the principles behind various laboratory assays, detailing the preanalytical variables that can affect results and guiding the interpretation of findings. Real-world challenges in thrombophilia testing such as during pregnancy, the use of oral contraceptives, and monitoring anticoagulation therapy are specifically examined. Written in a clear yet comprehensive style, this book is aimed at thrombosis specialists, hematologists, laboratory scientists, and students. It provides extensive knowledge, practical guidance, and evidence-based protocols for thrombophilia testing, ensuring accurate diagnosis and effective management of this life-threatening disorder.

Microbiome in Cancer and Autoimmunity - Part A, Volume 394 offers a comprehensive exploration of the intricate relationship between the human microbiome and the development of cancer and autoimmune diseases. Delving into cutting-edge research and clinical insights, this groundbreaking work elucidates the role of microbial communities in influencing immune responses, disease pathways, and therapeutic outcomes. From deciphering the molecular mechanisms underlying microbiome-host interactions to unraveling the impact of dysbiosis on disease progression, the book provides a multifaceted analysis of the microbiome's pivotal role in cancer and autoimmunity. With contributions from leading experts in the field, this book serves as a pivotal resource for researchers, clinicians, and healthcare professionals seeking to understand and harness the therapeutic potential of the microbiome in combating cancer and autoimmune conditions.

Microchemical Engineering and Technology focuses on the development, basic principles, characteristics, and advantages of micro chemical technology. The book summarizes the basic laws of micro-scale single-phase flow, the micro-scale mixing process, and the enhancement of micro-scale mixing performance. It introduces gas-liquid, liquid-liquid, and gas-liquid-liquid micro-dispersion equipment and dispersion law, micro-scale heat/mass transfer performance, as well as homogeneous and heterogeneous micro-scale reactions, micro-scale absorption, extraction, and reaction processes enhancement technology.For the application of microchemical technology in the area of material interpretation, nano material preparation technology, fiber material preparation technology and special structure material preparation technology are introduced. Final content describes typical cases of industrial applications of gas-liquid absorption micro chemical equipment, liquid-liquid extraction micro chemical equipment, and chemical synthesis micro chemical equipment. - Characterizes the close integration of theory and practice - Discusses basic theories of micro chemical technology - Analyzes industrialization trends of micro chemical technology

The idea that the mind and the body work together to create human well-being is no longer at the fringes of academia. Evidence-based courses in mind-body wellness typically explore how physical and emotional wellbeing are related to biological, psychological, sociocultural, economic, and spiritual factors, as well as the ways in which our beliefs about the relationship of mind and body relate to how we view health and illness. Research points to a dynamic interconnectivity of mind and body processes that can support human wellness and can be a point of intervention for practices that improve wellbeing. Mind-Body Wellness: A Science-Based Approach begins with an overview of what mind-body interconnectivity means, approaches to defining wellness, and philosophical and practical approaches to mind-body wellness. Subsequent chapters address foundational topics in the field, including theories of behavior change, stress and wellness, mind-body practices, environmental wellness, and relationship wellness. The book ends with consideration of how mind-body wellness can not only impact our personal wellbeing, but also societal wellbeing.

This book explains MRI pulse sequences in a simple, easy-to-understand way. As MRI use grows rapidly due to its detailed imaging and faster technology, it's important for radiology trainees to learn core pulse sequences early. The authors clearly describe the physics behind commonly used clinical MRI sequences, like spin-echo, gradient-echo, and MR angiography, etc., while simplifying complex concepts and including clinical examples. The book also addresses challenges in MRI education and standardization, offering a comprehensive guide for radiologists, residents, physicists, researchers, and students.

This book offers a comprehensive review of essential medical knowledge topics that pain fellows need to acquire to successfully graduate a Pain Medicine Fellowship Program. It enhances local curriculum in pain fellowships across the nation and offers standardized education of trainees while also serving as a reference for practitioners and trainees worldwide. The book serves several purposes: Guides and standardizes teaching curriculum for the 120 ACGME accredited pain fellowships and about 200+ non-ACGME accredited fellowships Offers trainees key references essential for their education and future career development Serves as board preparation material Guides pain program directors on developing a program-specific and fellow-specific curriculum tailored towards own institution Chapters follow a natural progression from basic science to topics on interventions, surgeries and emerging techniques in pain medicine. The reader is guided and directed towards concepts needed for progressing into becoming competent pain physicians. Together with introduction of essential topics in pain medicine, each chapter is introducing key publications that are requisite in learning the art and science of pain medicine. In the time where pain medicine is such a dynamic and innovation incubator, Multidisciplinary Pain Medicine Fellowship, will ensure that next generations of pain practitioners speak the basic common language of our specialty and advance best practices in pain medicine.

This book offers a comprehensive exploration of the cutting-edge multi-omics technologies that are revolutionizing research across biomedical sciences and environmental sustainability. It addresses the urgent need for interdisciplinary research by integrating multi-omics approaches with bioinformatics and artificial intelligence. The book explores evolution of traditional omics technologies into comprehensive multi-omics strategies that synergize data output through advanced computational tools. It covers diverse topics such as health and disease mechanisms, drug discovery innovations, COVID-19 responses, cancer treatment personalization, neuroscience insights into brain disorders, cyanobacterial natural compounds' potential for biofuel production, lichen symbiosis studies, and more. This volume integrates genomics, proteomics, metabolomics, and more with bioinformatics, machine learning, and artificial intelligence to address complex challenges in health and the environment. With contributions from renowned scholars worldwide, this book illuminates recent advances through illustrative figures and case studies that enhance understanding of complex pathways while bioinformatics strategies streamline research outcomes. This book is a must-read for researchers, academics, and professionals in life sciences, biomedical fields, and environmental studies, interested in advancing their knowledge of multi-omics applications. It is also beneficial for scientists involved in drug design or biotechnological innovations related to environmental sustainability.

This book will concentrate on ultrasound findings in musculoskeletal (MSK) conditions, presenting cases of various MSK conditions based on their ultrasound features. The target audience includes medical students, orthopedists, rehabilitation physicians, rheumatologists, pain physicians, physiotherapists, etc. Each MSK condition will be illustrated with clinical features, relevant physical examination findings, and imaging, including X-rays and high-frequency ultrasound. None of the cases have been previously published in other books; all are derived from real patients, with a focus on community-based facilities and tertiary-level practices. Case discussions will be followed by a suggested reading list.

Myasthenia Gravis, Part A, Volume 182 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as the Structure of the NMJ and Neuromuscular Transmission, Neuromuscular Junction and the Complement System, Regulation of the Autoimmune Response, The Thymus, Antibodies/Subclasses (IgG) and Antigens, Cell Models of MG, Mouse Models of EAMG and Passive Immunization, Epidemiology of Myasthenia Gravis, Special Populations: Juvenile, Early, Late, and Very Late-Onset, Blood and Digital Biomarkers in MG, Lambert-Eaton Myasthenic Syndrome, and Congenital Myasthenic Syndromes.

Thoroughly updated and expanded, the second edition of Neonatal Infections is intended as a quick-reference guide for the busy clinician caring for newborns and young infants, whether in the nursery, the ward, the clinic, or the intensive care unit. It covers infections acquired during birth or while in the hospital (Part 1), as well as congenital infections acquired in utero (Part 2). Summary chapters regarding infection control and prevention, outbreak management, diagnosis of infection, antibiotic stewardship, and immunizations are also included (Part 3). Neonatal Infections is a concise yet thorough and visual handbook for infectious disease specialists, neonatologists, pediatricians, family practitioners, medical students, hospitalists, nurses, and all clinicians caring for infants in the nursery or neonatal intensive care unit.

It is truer in neurology than in any other system of medicine that a firm knowledge of basic science material, that is, the anatomy, physiology, and pathology of the nervous system, enables one to readily arrive at the diagnosis of where the disease process is located and to apply their knowledge at solving problems in clinical situations. The purpose of this textbook is to enable a neuroscientist to discuss the structure and functions of the brain at a level appropriate for students at many levels of study including undergraduate, graduate, dental, or medical school level. The authors have a long experience in teaching neuroscience courses at the first- or second-year level to medical and dental students and to residents in which clinical information and clinical problem-solving are integral to the course. The authors reach this object by integrating basic sciences with neurological clinical cases containing MRI, CT or fMRI images.

This book provides detailed information about neuromonitoring in thyroid and parotid surgery. In an easy-to-learn format, this book presents the reader with indications and rationale for neuromonitoring use, differences between intermittent and continuous neuromonitoring in thyroid surgery, a detailed description of how to do it in open and endoscopic approaches, loss of signal and how to proceed, outcomes, and neuromonitoring in robotic surgery. Detailed information about how to use neuromonitoring in parotid surgery is also presented. This book is the expert all surgeons need to correctly use neuromonitoring in thyroid and parotid surgery.

The Neuroscience of Feelings: Brain-Heart Connectivity in Neurodegenerative Diseases, Volume 294 explores the complex interplay between emotions and brain function+G147, covering topics such as The role of heart-brain connectivity in neurodegeneration: mechanisms and impacts, Cardiovascular influence on cognitive decline: the heart's role in neurodegenerative disorders, Autonomic nervous system dysregulation in neurodegenerative diseases: bridging brain and heart, Heart rate variability as an indicator of brain health in neurodegeneration, and much more. Other sections cover Emotional stress and cardiovascular health: impacts on neurodegenerative disease progression, Exploring heart-brain axis alterations in Parkinson’s disease, Cardiac biomarkers as predictors of cognitive decline in neurodegenerative conditions, Heart-brain synchrony: therapeutic implications for neurodegenerative disease, and Neurocardiology and neurodegenerative diseases: emerging research on emotional regulation and brain-heart connectivity.

This book contains the papers of the 9th International Workshop on Medical and Service Robots (MESROB) which was held in Poitiers, France, on July 2-4, 2025. The main topics include: design of medical devices, kinematics and dynamics for medical robotics, exoskeletons and prostheses, anthropomorphic hands, therapeutic robots and rehabilitation, cognitive robots, humanoid and service robots, assistive robots and elderly assistance, surgical robots, human–robot interfaces, haptic devices, medical treatments, medical lasers, and surgical planning and navigation. The contributions, which were selected by means of a rigorous international peer-review process, highlight numerous exciting ideas that will spur novel research directions and foster multidisciplinary collaboration among different specialists, demonstrating that medical and service robotics will drive the technological and societal change in the coming decades. Chapter "A Pneumatic HandHeld Device for Finger Active Tele-rehabilitation" is available open access under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License via link.springer.com.

This book presents an approach to the integration of healthy behaviors in clinical practice based on cutting edge science. It has been authored and edited by a select group of national and international experts in their respective fields who have developed these concepts for application in routine practice. This second edition of Nutrition, Fitness, and Mindfulness uses three major categories to discuss healthy behavior: healthy eating, active living, and mindfulness. All chapters are formatted to provide key learning points and summarized conclusions for easy reference. Eighteen chapters of the first edition have been updated in this new edition and cover such topics as the DASH diet, plant-based nutrition, the Mediterranean diet, beneficial herbs and spices, fitness, spirituality, meditation, healthy sleep, and disease prevention. 7 new chapters have been added, covering ultra-processed foods, food as medicine, integrating dietary patterns into the cultural preference, multicompartment exercise strategies for improving health in older adults with comorbidities, as well as chapters on evidence-based lifestyle interventions in risk of genitourinary cancer, diabetes, and barriers to a healthy lifestyle. Nutrition, Fitness, and Mindfulness: An Evidence-based Guide for Clinicians is a comprehensive guide aimed at all clinicians and healthcare professionals encouraging patients to make more thoughtful and healthy lifestyle choices.

This book offers a comprehensive overview of the ophthalmic considerations and components of the popular sports including football, hockey, tennis, basketball, motorsports, and more. Written with experts in the field who have been involved at the highest level including the NBA, NHL, NCAA, Formula 1, NFL, ATP, and the Olympics, the chapters in this book are designed to provide expert insight and comprehensive information on ophthalmic components of sports including vision performance, ocular trauma, and neuro-ophthalmic principles. The book seeks to be a helpful compendium to a wide audience including primary care providers, ophthalmologists, sports medicine physicians, athletes, referees, and sports performance coaches looking to optimize athlete performance. From the medical clinic to the sports field, Ophthalmology of Sports serves as a helpful resource for all who are involved with sports.

This book examines the diagnostic usefulness of otoacoustic emissions (OAEs) in the context of theoretical cochlear mechanics. OAEs have proven to be immensely useful for diagnostic purposes. The phenomenology of hearing physiology, and OAEs in particular, is briefly summarized, providing the necessary references to the literature. State-of-the-art linear and nonlinear mathematical models of the cochlea are discussed, using fundamental concepts of fluid dynamics and mechanics of vibrating systems, often exploiting the formal analogy between mechanical and electric linear systems. In particular, it is explained how the theoretical predictions about the OAE level, phase, and nonlinear I/O functions allow one to design advanced acquisition and analysis tools that significantly improve the specificity and sensitivity of OAEs to hearing dysfunction and other important physiological effects. Examples of diagnostic applications of OAEs in audiology, neurology, and space physiology are discussed, with all of the information needed to develop an OAE experiment provided, from instrument and acquisition setup to signal analysis and theoretical interpretation. The book is targeted at graduate students and researchers in hearing science with at least a basic knowledge of classical physics, calculus, Fourier analysis and signal analysis.

This book focuses on how to effectively support treatment engagement for patients with anxiety and related disorders. The text begins from the premise that individuals already face numerous logistical, environmental, and systemic barriers to evidence-based psychotherapy. Furthermore, among anxious populations, the very symptoms that require treatment—namely, avoidance and fear-based cognitions--can deter treatment seeking. Thus, it is critical to understand how best to support treatment engagement once access barriers are overcome. Summarizing the state of the research and integrating practical application, this volume lays out the ways to maximize patient engagement and optimize treatment outcomes in cognitive behavioral treatments for the range of anxiety and related disorders. The reader will gain: !-- [if !supportLists]--· !--[endif]--Theoretical understanding of the treatment engagement process !-- [if !supportLists]--· !--[endif]--Knowledge about common barriers to treatment engagement across anxiety, obsessive-compulsive, and posttraumatic stress disorder !-- [if !supportLists]--· !--[endif]--Clinical strategies and practical guidance for optimizing treatment engagement

The most comprehensive volume of its kind, The Oxford Handbook of Mood Disorders provides detailed coverage of the characterization, understanding, and treatment of mood disorders. Chapters are written by the world's leading experts in their respective areas. The Handbook provides coverage of unipolar depression, bipolar disorder, and variants of these disorders. Current approaches to classifying the mood disorders are reviewed and contemporary controversies are placed in historical context. Chapter authors offer a variety of approaches to understanding the heterogeneity of the experiences of those who meet criteria for mood disorders, both within and across cultures. The role of genetic and environmental risk factors as well as premorbid personality and cognitive processes in the development of mood pathology are detailed. Interpersonal, neurobiological, and psychological factors also receive detailed consideration. The volume reviews mood disorders in special populations (e.g., postpartum and seasonal mood disorders) as well as common comorbidities (e.g., anxiety, substance use disorders). Somatic and psychosocial treatment approaches receive in-depth coverage with chapters that describe and review empirical evidence regarding each of the most influential treatment approaches. The depth and breadth offered by this Handbook make it an invaluable resource for clinicians and researchers, as well as scholars and students.

The fourth edition of Pathology of Asbestos-Associated Diseases builds on the success of the previous editions by fully updating knowledge on diagnostic and epidemiologic aspects and presenting important new insights derived from new epidemiologic studies and animal studies. This book is the primary text related to the pathology of asbestos-associated disease. Background information is first provided on the mineralogy of asbestos, occupational and environmental exposure, and asbestos bodies. The various diseases associated with asbestos exposure are then considered in turn, with detailed description and illustration of pathologic features as well as extensive discussion of etiology, epidemiology, differential diagnosis, treatment, and prognosis. Further chapters are devoted to cytopathology, experimental models of disease, analysis of tissue mineral fiber content, and medicolegal issues. It will also discuss the medicolegal aspects of asbestos-related diseases from both a plaintiff's attorney's perspective as well as a defendant's attorney's perspective. All chapters are updated to match the current understanding of asbestos-related disease, and will include new research based on current issues concerning possible contamination of talc with asbestos. This new edition also considers the role of non-asbestiform cleavage fragments in disease pathogenesis. Written by experts in the diagnostic, epidemiologic, and medicolegal aspects of asbestos-related diseases, this book helps readers understand how different types of asbestos fibers contribute to disease pathogenesis and in determining causation of disease in specific cases. This book will be an essential reference for pathologists and an invaluable source of information for pulmonologists, radiologists, and occupational medical practitioners.

Accessible, practical, and focused on diagnosis and treatment, Pediatric Gastrointestinal and Liver Disease, Seventh Edition, covers the entire spectrum of pediatric GI, hepatic, and nutritional disorders. This popular reference offers definitive guidance from experienced editors Drs. Robert Wyllie, Jeffrey S. Hyams, and Marsha Kay, as well as globally renowned contributors who share their knowledge and expertise on complex issues. Full-color illustrations, review questions online, real-world case studies, and detailed instruction on performing key procedures ensure that this updated edition remains your reference of choice in this fast-changing area. - Includes significantly updated coverage of the gut microbiome; new biologic therapies for the treatment of pediatric inflammatory bowel diseases; advancements in the treatment of pediatric liver diseases, including metabolic-associated fatty liver disease (MAFLD); and new diagnostic imaging techniques. - Features a robust art program with full-color anatomical figures, clinical photos, and other illustrations throughout the text. - Details key procedures such as esophagogastroduodenoscopy and related techniques; colonoscopy and polypectomy; endoscopic retrograde cholangiopancreatography and endoscopic ultrasound; capsule endoscopy and small bowel enteroscopy; GI motility procedures; and more. - Prepares you for certification and recertification with more than 400 board-style review questions, answers, and rationales online. - Contains numerous algorithms that provide quick and easy retrieval of diagnostic, screening, and treatment information, as well as detailed diagrams that accurately illustrate complex concepts and provide at-a-glance recognition of disease processes. - An ideal everyday resource for pediatric gastroenterologists and hepatologists, pediatric dieticians and nutritionists, pediatricians, family medicine practitioners, PAs, and NPs. - Any additional digital ancillary content may publish up to 6 weeks following the publication date.

The prevalence of diabetes and obesity has increased over the past decade and is expected to continue to rise until at least 2030. There is a clear association between diabetes and obesity due to insulin resistance, chronic inflammatory state, and endothelial dysfunction. Since diabetes and obesity are commonly encountered chronic conditions, pharmacists and associated trainees are in a unique position to collect and assess information about these issues within the communities they serve. With the help of the expert advice in The Pharmacist’s Pocket Guide for Diabetes and Obesity, pharmacists, trainees, and other health care professionals can develop and implement a person-centered plan with appropriate monitoring and follow-up to omtimize outcomes for patients with diabetes and obesity. The Pharmacist’s Pocket Guide for Diabetes and Obesity has separate sections on diabetes and obesity which include the clinical assessment, pharmacological and non-pharmacological interventions, management of complications, and information on special populations for each condition. The text wraps up with a section on the pharmacist's role in clinical scenarios and another on the future of research and practice in pharmacy. This book fills a gap in the existing literature by providing a conveniently sized, quick-reference guide full of practical strategies, tips, and considerations for patients with diabetes and obesity for a broad audience of pharmacists, trainees in pharmacy, and other health care professionals.

This book focuses on how to effectively support treatment engagement for patients with anxiety and related disorders. The text begins from the premise that individuals already face numerous logistical, environmental, and systemic barriers to evidence-based psychotherapy. Furthermore, among anxious populations, the very symptoms that require treatment—namely, avoidance and fear-based cognitions--can deter treatment seeking. Thus, it is critical to understand how best to support treatment engagement once access barriers are overcome. Summarizing the state of the research and integrating practical application, this volume lays out the ways to maximize patient engagement and optimize treatment outcomes in cognitive behavioral treatments for the range of anxiety and related disorders. The reader will gain: !-- [if !supportLists]--· !--[endif]--Theoretical understanding of the treatment engagement process !-- [if !supportLists]--· !--[endif]--Knowledge about common barriers to treatment engagement across anxiety, obsessive-compulsive, and posttraumatic stress disorder !-- [if !supportLists]--· !--[endif]--Clinical strategies and practical guidance for optimizing treatment engagement

Have you ever experienced the calming effect of a deep breath? With this guide, you will learn how intuitive breathing can improve your quality of life. Targeted breathing techniques help you navigate your daily life with more calmness. Whether you suffer from chronic respiratory diseases like asthma and COPD, want to reduce pain, or strengthen your mental well-being and immune system – this guide offers practical exercises to help you consciously use your breath, bringing more peace, energy, and balance into your life. From the contents: The universal power of breathing and its history, the anatomy and functioning of the respiratory system, targeted breathing techniques for stress, inner tension, and healthy sleep, and the connection between breathing and meditation

Nothing is possible without the nose! We breathe, smell and taste with it. Smells warn us of dangers, and scents can awaken memories and feelings. All without including the mind. The nose decides who we find seductive or who we simply can't smell. We often only realize how important smell is when illnesses like corona rob us of this sense. Everyone's scent preferences are individual. Just like our own scent, which sends out messages and helps us find a partner. The exciting thing is: We don't just perceive these messages with our nose; scents have an effect on the whole body. As the latest scientific research has shown, they can also accelerate the healing of wounds, change the heartbeat and improve hair growth and digestion. They also influence the brain: we may become calmer or more active. Even tumor cells react to scents and reduce their growth. Conversely, tumor cells themselves emit odorous substances, which trained dogs can recognize. This book is a translation of the original German edition “Die Lust am Duft” by Hanns Hatt and Regine Dee, published by Springer-Verlag GmbH, DE in 2023. The translation was done with the help of an artificial intelligence machine translation tool. The authors subsequently revised and added new content, and the text was copy-edited to enhance its style.

This book serves as an invaluable resource for physicians utilizing ultrasound in their practice, emphasizing its crucial role in imaging and guidance for pain interventions. It introduces and explores the concept of "sonoanatomy," offering a practical and concise guide for pain and musculoskeletal specialists. The application of ultrasound has grown significantly across various clinical disciplines in recent years. In pain management, it has become a practical and widely adopted tool. By using ultrasound, clinicians can improve the success rates of pain interventions while reducing the risk of complications. Compared to fluoroscopy and CT, ultrasound is more convenient; however, it requires a solid understanding of clinical anatomy and hands-on experience for effective and safe application. "Sonoanatomy" refers to the integration of detailed anatomical knowledge with ultrasound imaging. Mastery of sonoanatomy is essential for accurately targeting structures during pain interventions. This synthesis of anatomy and practical ultrasound techniques is the cornerstone of successful procedures. The book prioritizes sonoanatomy while detailing relevant techniques. Designed as a concise guide, it is tailored for physicians across specialties, including residents and specialists in physical medicine and rehabilitation, anesthesiology, pain medicine, and anatomy. It also serves as a valuable reference for all clinicians involved in ultrasound-guided procedures.

This book provides detailed guidance and tips on using ultrasound and other non-invasive techniques for inserting central venous catheters. It also offers advice on the available equipment, manoeuvres for accessing the venous system, and techniques for evaluating tip placement. Moreover, it provides a complete view of the prevention, diagnosis, and management of catheter-related complications (infection, thrombosis and dislodgment) and instructions on catheter care and maintenance. A hint at emerging technologies and techniques for central venous cannulation is also included. Central venous access devices have become a fundamental tool in daily clinical practice, especially in ICU settings and in the management of oncology patients, where all physicians are expected to know what, when and how to place such devices. In addition, oncology patients need these devices in the early stages of active treatment and in the end phases for palliative measures. As of today, totally implantable venous access devices are considered safe, reliable, and effective for administering chemotherapy and parental treatment, with a low morbidity and complication rate. Primarily focused on illustrating practical and operative instructions, this book will be an invaluable tool for many professionals, including oncologists, anaesthesiologists, radiologists, surgeons, registered nurses, nurse practitioners, nutritionists, physicians and physician assistants.

Prediction of the Future Pandemic: Artificial Intelligence and Nanotechnology Approaches provides a comprehensive account of the applications, challenges, and breakthroughs in using AI and nanotechnology for pandemic prediction. The book emphasizes interdisciplinary collaboration among experts and a global perspective on the prediction of future pandemics. Sections provide a comprehensive exploration of cutting-edge methodologies that leverage AI and nanotechnology to predict, analyze, and combat future pandemics. This book aims to bridge the gap between theoretical concepts and practical applications, offering insights into the integration of these advanced technologies for more accurate, timely, and ethical pandemic predictions. - Offers an in-depth examination of the integration of AI and nanotechnology in pandemic prediction - Covers many nanotechnology applications in pandemic prediction, such as nanorobotics for targeted intervention, the role of nanomaterials in prevention strategies, viral detection/nanosensors in quarantine enforcement, and nanocomposite resilience (building pandemic-proof materials) - Helps readers get to grips with the fast-evolving landscape of AI, nanotechnology, and global health - Covers both the theory and real-world applications of AI and nanotechnology in predicting pandemics - Discusses the fast-changing connection between AI, nanotechnology, and pandemic prediction

Primary Brain Tumors in Adults: Advances in Mechanistic Understanding, Evaluation, and Management, Volume 166 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Molecular drivers in primary brain tumor formation, Novel CSF pathways in the glioma (DIPG), Volumetric analysis in low grade gliomas and other advanced MR imaging techniques, Liquid biopsy in the diagnosis of primary brain tumors, Intraoperative imaging techniques to improve tumor detection, and much more. Additional chapters focus on Supramaximal resection in primary brain tumors, Radiotherapeutic approaches: IMRT, re-irradiation, Molecularly driven therapies in the treatment of primary brain tumors, and Changes in the immune microenvironment and immunotherapeutic strategies in the treatment of gliomas.

Hormones—such as estrogens, testosterone, thyroid hormones, and growth hormone—are essential for metabolic homeostasis in all cells. However, their levels decline with age, contributing to aging and chronic disease. Proper hormone therapy can help delay the onset of age-related diseases, yet there is currently no authoritative, up-to-date resource on precision hormone optimization for healthy aging. Current standard of care textbooks rely on outdated concepts, while books aimed at non-specialist clinicians and patients are often written by non-experts and lack a solid scientific foundation. This book bridges that gap by presenting cutting-edge scientific data and insights from leading academic and private practice experts on the role of hormone optimization in healthy aging. It dispels common misconceptions about hormone therapy risks and highlights the proven benefits of precision hormone treatments. Drawing on both scientific evidence and clinical experience, it explores the distinctions between synthetic hormones and bioidentical, physiological hormones. Designed to challenge conventional thinking, this book aims to inspire discussion and further research among scientists and healthcare practitioners. It is an essential resource for basic and clinical researchers seeking translational knowledge on hormone therapy, as well as clinicians looking to integrate hormone optimization into their practice.

Protein Aggregation - Part B, provides valuable insights into the factors driving protein aggregation, the impact on cellular function, and the role in various diseases, offering a comprehensive overview for researchers and professionals in the field of biomedicine and biochemistry. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike

This book explores the role of proteostasis in neurodegenerative disorders, focusing on protein homeostasis in long-lived, nondividing cells like neurons. It examines how disruptions in proteostasis, influenced by factors such as oxidative stress, aging, and environmental stress, contribute to diseases like Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis. The book begins with an overview of the epidemiology and management of neurodegenerative diseases. Subsequent chapters delve into the mechanisms governing proteostasis, highlighting the ubiquitin-proteasome system, molecular chaperones, and co-chaperones in protein folding and degradation. It further explores how impairments in these pathways contribute to neuroinflammation and disease progression. By providing insights into these cellular processes, the book aims to enhance understanding and support the development of potential therapeutic strategies.

This book focuses on a holistic approach to providing care to patients with rheumatic illnesses that goes beyond the biomedical approach to include the psycho-social and cultural needs of patients. A diagnosis of a chronic rheumatic illness can dramatically affect all aspects of a person’s life. These life-altering conditions are characterized by physical pain and inflammation that may reduce or impair functioning of one or more parts of the musculoskeletal system and in some cases impact other organs throughout the body. Often accompanying these physical manifestations of the rheumatic illness are the psychological and social aspects that affect one’s overall health and quality of life. Due to the chronicity of many rheumatic illnesses, managing and coping with the illness is often an ever-evolving process that can span throughout the developmental spectrum or lifespan of the patient experience. A strictly biomedical approach to the treatment of rheumatic illnesses often fails to address these key aspects of the patients' overall well-being. A more comprehensive approach, inclusive of the bio-psycho-social-cultural lens, with the patient’s voice at its core, is needed to inform and ultimately deliver quality patient care and achieve optimal health outcomes. This book serves as s a tool for the entire interdisciplinary rheumatology health care team. This comprehensive approach is framed within the context of well-documented health disparities in rheumatology with a focus on psycho, social, emotional and environmental aspects of health that contribute to patient quality of life. It explores the needs of special populations and provide opportunities for clinicians to consider how to treat diverse populations in a more inclusive way. At the center of this book is the patient’s voice utilizing patient stories to provide the reader with real life examples that reflect the life cycle of rheumatology patients and the impact of key interventions or lack thereof that can impact the patient experience. Lastly, the book offers practical, evidence-based strategies for members of the rheumatology health care team. These tools can be integrated in their assessment and treatment plans for patients and their loved ones. This holistic approach can help to foster effective communication, build trust, enhance partnerships and amplify the patient voice to optimize health outcomes and enhance overall well-being.

This third edition provides a definitive, comprehensive, and multidisciplinary reference for a diverse healthcare audience to navigate the complexities of radiology service planning, implementation, and diagnostics in low and middle-income countries (LMICs) and resource-limited medically underserved regions. This book integrates clinical approaches with concepts of project planning to assist radiology professionals, public health specialists, and students to implement medical imaging in under-served and resource-constrained contexts to improve global health outcomes and optimize the use of radiologic technologies. The first section of the book introduces the general role of radiology in international public health, to help readers (i) understand the impact of medical imaging on health disparity (ii) learn how to assess radiologic service infrastructure in low-resource environments, and (iii) learn how to plan projects aiming to address health care shortages. The second section of the book presents clinical contexts for deploying radiology such as pediatrics, trauma, infectious disease, and cancer control. Themes from the two sections are interwoven so that the learner can integrate concepts of project development with clinical objectives. For example, the chapter on information technology (IT) reinforces the chapter on cancer control by addressing IT solutions applicable to cancer management in medically underserved areas. All chapters have been fully updated and this edition adds chapters on artificial intelligence, COVID, and breast imaging, as well as others. This is an ideal guide for radiologists and medical professionals working in LMICs and resource-limited medically underserved regions.

Recent Advances in Liver Cirrhosis Related Complications provides comprehensive coverage of the contemporary management of liver cirrhosis related complications and provide future directions for the field. Content covers epidemiology, diagnosis and risk stratification, and pathophysiology of liver cirrhosis. Contents include coverage of the gut microbiota, ascites, and gastrointestinal bleeding as well as the challenges of hepatic encephalopathy, acute kidney injury, bacterial infections, coagulation abnormality and venous thromboembolism, among others. This is the perfect resource for practicing gastroenterologists and hepatologists as well as family physicians and investigators who are skilled at the management of liver cirrhosis and its complications. - Outlines the contemporary management of various liver cirrhosis complications and provides future directions of the field - Includes the most updated research findings - Contains comprehensive coverage of the complications related to liver cirrhosis

The volume 2 of this book covers the recent developments in various aspects of this new branch of surgery. Minimal Access Surgery (laparoscopic and robotic surgery) has advanced tremendously in the last few years. This volume provides step-by-step descriptions accompanied by numerous helpful photographs and anatomical drawings. It also covers the controversies and gives a cumulative opinion on the recent advances in MAS including MAS in oncology. Further topics are based on system wise and all volumes have separate chapters on the different topics within the system. This volume fills the void of a manual in minimal access surgery which benefits all, including the students of fellowships MAS, Master of Surgery, DNB Surgery and also young faculty or any practitioner.

This book provides useful information on dealing with remote consultation, exploring the most frequent clinical scenarios and offering guidance on managing patients. It represents a comprehensive manual on remote consultation, whether conducted by phone or video, structured in 4 sections. The first section presents the need for a paradigm shift and describes the epidemiology of remote consultation. It also addresses the feasibility and features of remote consultation in rural and low-income settings. The second part guides the reader through the various steps of a consultation, emphasizing the significance of considering those phases as consequential and all having paramount importance. It also showcases different models for triage and consultation. The third part of the book presents the most frequent clinical scenarios encountered. Finally, the fourth part explores the future landscape of consultation. This book will be a valuable tool for Family Physicians, any other physician involved in remote consultation, and nurses.

The emerging role of gut microbiota and postbiotics has implications for the management of not only human health and diseases, but also colorectal cancer in particular, as these elements influence colorectal cancer pathogenesis, treatment, and prevention. This book bridges the gap between cutting-edge research and practical clinical applications in the management of colorectal cancer by offering a fresh perspective on potential therapeutic strategies and exploring the significance of microbiota in the oncology landscape. Chapters delve into the specific impacts of postbiotics, linking them to immune response modulation, inflammation reduction, and direct anticancer effects. Chapters also explore current and emerging therapies, including the manipulation of gut microbiota and the use of postbiotics supplements. Clinical trial results, case studies, and expert opinions are interwoven to present a realistic view of the benefits, limitations, and future prospects of these innovative therapeutic strategies. This book is rounded out with perspectives on future research directions in this area, discussing potential next-generation therapies such as personalized medicine approaches and biotechnological advancements, and further contemplating broader implications of microbiota research on public health strategies. Informative and engaging, this book provides clinicians and researchers alike with a deeper understanding of how postbiotics can be harnessed in colorectal cancer treatment and potentially, the treatment of other cancers influenced by gut health.

This book equips nurses and midwives with a role in providing vaccination services in the UK with the information they need to practice safely and effectively. This includes ensuring they are equipped to answer questions as they arise. Starting with the importance of vaccination for public health, the book takes a vaccination through the life course approach from pregnancy, babies and childhood, teenagers, adults to older people discussing some of the key challenges and issues with the different vaccine programmes. The book provides readers with the best practice guidance to offer a safe effective and quality service. To maximise the uptake of vaccination across the population, it offers guidance on how to ensure vaccination is offered to and accessible to all those who are eligible. Information is offered on how to address parents’ and patients’ questions and concerns effectively, to ensure they are provided with the evidence-based information they need to make an informed decision about vaccination and be able to give informed consent. This book also provides technical information on vaccine preparation, injection techniques and how to minimise the pain and distress of vaccination; it also provides clinical management support for patient observation after vaccination. Each chapter is written by nurses and midwives expert in immunisation and vaccine administration, with contributions from physicians, legal and pharmacy professionals where relevant.

The Science of the Brain: Function, Dysfunction and Disease is an innovative exploration into the complex interplay between brain functionality and various neurological disorders, meticulously compiled by a world-renowned researcher. This groundbreaking book presents a comprehensive analysis, offering the first complete theories for eleven major brain disorders, including Alzheimer's, schizophrenia, and autism spectrum disorder, among others. Each chapter delves into a unique theoretical framework, from lipid raft theories to sympathetic nervous system impacts, all while proposing potential treatment targets grounded in established scientific data. In addition to two chapters that lay the groundwork for understanding brain adaptability and anatomy, other chapters independently dissect each disorder, revealing fresh insights that promise to invigorate research and clinical application. This essential resource not only serves neuroscientists and clinicians seeking a deeper understanding of brain disorders but also invites entrepreneurs interested in novel therapeutic avenues. With its rich references and pioneering theories, this book is poised to become indispensable to students, researchers and clinicians, paving the way for future discoveries in brain health and disease management. - Identifies connections between brain functionality and specific disorders, revealing previously unexplored therapeutic avenues - Challenges existing paradigms in neuroscience by presenting the first comprehensive theories for a range of neurological and psychiatric conditions - Utilizes detailed references and robust scientific data to support groundbreaking claims and methodologies

This open access book offers comprehensive coverage of all relevant aspects of shoulder fractures, also known as fractures of the proximal humerus, with a special focus on existing controversies in their treatment. Throughout the volume the author outlines the development of the modern scientific understanding in the field and the increasing operative approach to these injuries throughout the 20th century. The volume is subdivided into five sections, the first of which introduces shoulder fractures, their morphology and epidemiology. The second one presents their history, from the earliest known medical text in ancient Egypt to the mid-twentieth century. In the third part, the author discusses the challenges implied in understanding and translating fracture patterns into hierarchies and classification systems. Based on current clinical trials, part four casts new light on the existing tension between an increasing interest in surgical procedures and implants, and the failure of emerging empirical evidence to demonstrate benefits for the vast majority of patients. In the book’s conclusions, elaborating on this evidence, the author shares his reflections on the changing approaches to shoulder fractures and interprets them within a broader context of intellectual history. This book appeals to a broad readership, including orthopaedic residents, shoulder surgeons, traumatologists, and other clinical decision-makers, and those with an interest in evidence-based practice and the history and philosophy of medicine.

This book offers researchers and practitioners a concise and accessible guide to the essential concepts in statistics, emphasizing their proper application. It encourages readers to delve deeper into the fascinating field of statistics, a branch of mathematics that enhances our understanding of the world around us. Designed to provide enough material for a short introductory course, Statistics for Scientists caters to students at all levels. It emphasizes real-world applications, providing scientists with the tools they need to conduct more reliable and valid studies, ultimately contributing to the advancement of scientific knowledge. Learn to interpret statistical results accurately and draw meaningful conclusions from your data, significantly contributing to the advancement of scientific knowledge. Structured to deliver a clear overview of statistics and data analysis for scientific research, the book begins with fundamental concepts, including random variables, outcome spaces, and the distinction between descriptive and inferential statistics. It then explores data types, measures of central tendency, dispersion, and position. The discussion continues with an examination of outliers and various methods for identifying them. As the chapters progress, more complex topics such as distributions, hypothesis testing, and regression analysis are introduced in a step-by-step manner. This structure makes the book suitable for readers ranging from beginners to those seeking a quick refresher. The author has selected key concepts that anyone interested in using statistics should be familiar with. Some topics, such as hypothesis testing, are covered briefly; a more comprehensive treatment would require a stronger background in statistics and mathematics (such as calculus). With pedagogical elements that include text boxes with Definitions, Examples, and Warnings, this book introduces the necessary concepts of statistics for scientists described in a short and concise way, enriched with tips and rigorous explanations. This book is an invaluable resource for scientists seeking to improve their data analysis skills and contribute to the growing body of scientific knowledge through rigorous and reliable research.

A central focus of the US Military is the Human Weapon System (HWS) and the optimization of this weapon system. Over the past decade, the Department of Defence has invested in programs termed Human Performance Optimization (HPO) programs. Human performance for the human weapon system is much different than the civilian athlete. Therefore, the human weapon system's rehabilitation and performance training requirements are different and must be considered. This book demonstrates the following to strength coaches and practitioners: Why to view the HWS as a multi-faceted system that requires a more inclusive program than needed by athletes. Provide updated methodology to create a strength and conditioning program specifically for the HWS populations. Introduce and define advanced strength and conditioning methodologies SC professionals use within the US Military and law enforcement performance programs.

This book introduces the specialized skills needed for assessing and managing strabismus, a condition made complex by its varied presentations and the numerous surgical options available. The aim of this book is to demystify complex strabismus management through expert, case-based presentations of clinical scenarios. These cases guide readers through a step-by-step planning process, detailing surgical techniques along with common and uncommon complications. Surgical Management of Strabismus uniquely compiles the vast experience and expertise of some of the most esteemed strabismus surgeons. This book serves as an essential reference for both established and aspiring surgeons, as well as for orthoptists and optometrists.

"This book introduces the precursors model of therapeutic change with difficult clients, including strategies to overcome barriers to working with them"-- Provided by publisher.

The second edition of Translational Neuroscience offers wide-ranging and insightful perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, rehabilitation, and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides detailed coverage of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. All of the first edition chapters have been extensively updated, and many new chapters have been added, including brain-machine interface, gene therapy, anti-sense oligonucleotides, and CRISPR. Among the many other topics covered are Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation, and clinical trial design/consideration.

This text outlines a practical guide for nurses and healthcare providers to provide care for individuals with varying traumatic histories with an informed perspective. Consideration of trauma as an acute experience to one that can develop into a post-traumatic stress disorder are explored. Additionally, the biological, behavioral, historical and cumulative basis of trauma are discussed as well as the family’s role in generational trauma. Trauma presents a complex multilayered experience that requires understanding to provide appropriate care. Trauma if often viewed as a physical experience with minimal consideration of the emotional and mental health aspects of these experiences. The perspective of unseen emotional scars is given descriptive graphic to allow the scars to be visualized and treated. The book includes perspectives across the globe from Thailand, UK, Philippines, India, Ireland, and Caribbean. As such this book will fill a gap in the field.

The book covers multiple aspects and challenges, from legal to technical and validation, in the emerging topic of AI in cancer imaging, bringing together the experience of top researchers and flagship projects. The aim of this book is to address the important questions: “How to design AI that is trustworthy”, and “How to validate AI trustworthiness” in the scope of AI for cancer imaging research. The book discusses overall considerations and the generation of a framework; preparing for trustworthy AI, including the data and metadata for quality, transparency and traceability; implementing trustworthy AI with algorithms and Decision Support Systems; and validating trustworthy AI. This is an ideal resource for researchers from technical and clinical research sites, postgraduate students, and healthcare professionals in cancer imaging and beyond.

This book provides an accessible and comprehensive exploration of the principles and mechanisms behind widely used medical diagnostic tools. Written in clear, simple language, it offers a deep understanding of these instruments, their functionality, and the underlying science, making it ideal for a broad audience, including medical professionals, educators, and curious readers. The book begins with foundational concepts such as electromagnetic radiation, analog and digital signals, and binary systems, before diving into detailed discussions of key diagnostic tools like the stethoscope, thermometer, and pulse oximeter. Advanced imaging technologies such as X-rays, CT scans, MRI, and PET scans are thoroughly explained, along with non-invasive tools like ultrasound scanners and glucometers. Each chapter emphasizes the real-world applications and significance of these devices, with simple explanations supported by illustrative examples and figures. Designed for mixed readership, this book provides insights into the science behind diagnostic tools while also fostering a deeper appreciation for their practical impact on healthcare.

This book demonstrates the potential of urine as a biomarker resource for early disease detection, covering the related theory, strategies, tools and findings. Biomarker is measurable changes associated with the disease. Blood, as a critical part of the internal environment, is closely monitored and controlled by the body to maintain homeostasis, especially in the early stages of diseases. In contrast, urine, as a form of waste excreted by the body, accumulates early and small changes of the body without homeostatic control. Accordingly, urine can offer an ideal resource for early biomarker discovery. The book discusses exciting preliminary applications of urine biomarkers for diseases affecting major biological systems. It is useful for scientists, clinicians, venture capitalists of related field. In the 2nd edition, most of the chapters are updated and reorganized according to the latest research. Many new chapters have been added to supplement the discussion of this area.

This book is a comprehensive, concise collection but a complete overview of a critical topic i.e. Vitamin D. There is no book available as yet exclusively on Vitamin D. For patients, the importance of Vitamin D holds across all age groups, both sexes, and for medical professionals, across all medical specialties existing today. Vitamin D is significantly and intricately related to all the human body's organ systems. This topic is of interest, significance, and relevance to every medical professional of all subjects and specialties, including postgraduate students of super specialty subjects across the globe. It is the talk and topic of today's research worldwide. This book encompasses Vitamin D in terms of its need and role, deficiency, excessive states, and its consequences and presentations. The chapters include information about vitamin D across pediatrics to geriatrics. This book is a crisp, easy-to-carry guide on Vitamin D, written by academicians and researchers. The authors are from relevant specialties concerned with Vitamin D, e.g., Gastroenterology, Endocrinology, Medical Oncology, Dermatology, Neurology, Pharmacology, Biochemistry, Preventive and Social Medicine, Pediatrics, to name a few. The chapters include the problem statement of its deficiency, laboratory estimation, clinical manifestations, interactions, and role in the well-being of various organ systems of the body. Additionally, it includes tables, figures, pictures, scans, and pictorial representations for lucid reading and easy understanding.