PICO is an important framework helping one generate a clinical patient-care question, and more recently in light of the proliferation systematic and other reviews, the clinical research question. If you have framed the question in advance, fill out the PICO box. If you are having difficulty framing the question, insert the relevant variables in to the box to generate the question.
Example: When providing an overview on micronutrient deficiencies within a global context, Powell and Butterly emphasize the importance of supplementation of Zinc and other micronutrients in preventing severe disability and possible death. You begin wondering if this information is of value in your pediatric population.
Clinical question: In children with zinc deficiency, how effective is zinc supplementation in improving growth and decreasing infection rates?
Powell C, Butterly JR. Chapter 7. Nutrition. In: Markle WH, Fisher MA, Smego RA, Jr.. eds. Understanding Global Health, 2e. New York, NY: McGraw-Hill; 2014.
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